Spine - Lumbar
Activ-L™ Artificial Disc / Aesculap, Inc. - Clinical Study to Evaluate the Safety and Effectiveness of the Aesculap Activ-L Artificial Disc in the Treatment of Degenerative Disc Disease. THIS STUDY IS NOW CLOSED TO ENROLLMENT.


TOPS Artificial Facet System / Impliant Ltd.  – For patients with low back pain and leg pain from moderate to severe lumbar stenosis accompanied by facet arthrosis and/or degenerative spondylolisthesis.


NUBAC™ Disc Arthroplasty System / Pioneer Surgical Technology, Inc. - This system will be compared to a total disc called “ProDisc”. This trial is for patients who have been diagnosed with single level, L4/L5, symptomatic degenerative disc disease of the lumbar spine and have failed at least six months of conservative treatment.


Trinity Evolution Lumbar / Orthofix Biologics -  A Radiographic And Clinical Study Evaluating A Novel Alogeneic, Cancellous, Bone Matrix Containing Viable Stem and Osteoprogenitor Cells In Posterior Lumbar or Transforaminal Lumbar Interbody Fusion.
 
Coming soon to lumbar:
Freedom® Lumbar Disc / AxioMed Spine Corporation – An IDE Study of the Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease.


Spine - Cervical
Trinity Evolution Cervical / Orthofix Biologics – A Radiographic And Clinical Study Evaluating A Novel Alogeneic, Cancellous, Bone Matrix Containing Viable Stem and Osteoprogenitor Cells In Patients undergoing Anterior Cervical Discectomy and Fusion.


DISCOVER™ /DePuy Spine: 1-Level Cervical Artificial Disc Replacement vs Fusion (ACDF) -  For patients with degenerative disc disease in the cervical spine.


Brain
Adherus™ Dural Sealant / Hyperbranch Technology, Inc. - A Pivotal Clinical Trial Evaluating the Safety and Effectiveness of Adherus Dural Sealant When Used as a Dural Sealant in Cranial Procedures.


Other Studies
Substance P Neuropeptide Levels in Saliva, Serum and Cerebrospinal Fluid in Patients With Spinal Disease / Sponsored by CNSA - This is a pilot study that is trying to determine if degenerative spinal pain causes the levels of a substance called “Substance P” to change in patients’ saliva, blood and/or cerebrospinal fluid.


CORDIS ENTERPRISE™ Vascular Reconstruction Device and Delivery System (Humanitarian Use Device) – for endovascular treatment of wide-neck, intracranial, saccular or fusiform aneurysms.


Boston Scientific Target NEUROFORM™ Microdelivery Stent System (Humanitarian Use Device) – for use in treatment of wide-neck, intracranial aneurysms.